COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation
نویسندگان
چکیده
منابع مشابه
COX-2: a pivotal enzyme in mucosal protection and resolution of inflammation.
The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause less gastric damage than conventional, nonselective COX inhibitors, but their use is still associ...
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The healing of gastric ulcer is a complicated process that involves the proliferation of epithelial and endothelial cells and the concerted actions of a wide range of growth factors. Prostaglandins play an important role in ulcer healing. Expression of cyclooxygenase-2 (COX-2) is markedly upregulated around the margins of gastric ulcers and its inhibition leads to a delay of ulcer healing. Seve...
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ژورنال
عنوان ژورنال: The Scientific World JOURNAL
سال: 2006
ISSN: 1537-744X
DOI: 10.1100/tsw.2006.122